8THK

Cryo-EM structure of A61603-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein

Summary for 8THK

• Entry DOI: 10.2210/pdb8thk/pdb
• EMDB information: 41267
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: alpha-1a-adrenergic receptor, a61603, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 160827.61

Authors

Su, M.,Huang, X.Y. (deposition date: 2023-07-17, release date: 2023-08-16)

• Primary citation: Su, M.,Wang, J.,Xiang, G.,Do, H.N.,Levitz, J.,Miao, Y.,Huang, X.Y.; Structural basis of agonist specificity of alpha 1A-adrenergic receptor; Nat Commun, 14:4819-, 2023; DOI: 10.1038/s41467-023-40524-2

Experimental method

ELECTRON MICROSCOPY (2.6 Å)