7S8P

CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134

Summary for 7S8P

• Entry DOI: 10.2210/pdb7s8p/pdb
• EMDB information: 24900
• Descriptor: Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 157810.55

Authors

Cao, C.,Fay, J.F.,Gumpper, R.H.,Roth, B.L. (deposition date: 2021-09-18, release date: 2021-11-17, Last modification date: 2021-12-15)

• Primary citation: Cao, C.,Kang, H.J.,Singh, I.,Chen, H.,Zhang, C.,Ye, W.,Hayes, B.W.,Liu, J.,Gumpper, R.H.,Bender, B.J.,Slocum, S.T.,Krumm, B.E.,Lansu, K.,McCorvy, J.D.,Kroeze, W.K.,English, J.G.,DiBerto, J.F.,Olsen, R.H.J.,Huang, X.P.,Zhang, S.,Liu, Y.,Kim, K.,Karpiak, J.,Jan, L.Y.,Abraham, S.N.,Jin, J.,Shoichet, B.K.,Fay, J.F.,Roth, B.L.; Structure, function and pharmacology of human itch GPCRs.; Nature, 600:170-175, 2021; PubMed: 34789874; DOI: 10.1038/s41586-021-04126-6

Experimental method

ELECTRON MICROSCOPY (2.6 Å)