7S8P
CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Gs-mini-Gq chimera | polymer | 246 | 28084.8 | 1 | Homo sapiens (Human) | ||
2 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | E | scFv16 | polymer | 267 | 28668.9 | 1 | Mus musculus (Mouse) | ||
5 | R | Soluble cytochrome b562,Mas-related G-protein coupled receptor member X4 chimera | polymer | 472 | 53422.1 | 1 | UniProt (P0ABE7) UniProt (Q96LA9) Pfam (PF00001) Pfam (PF07361) In PDB | Escherichia coli | Cytochrome b-562,Sensory neuron-specific G-protein coupled receptor 5/6 |
6 | R | N-[(1r,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-D-phenylalanine | non-polymer | 355.5 | 1 | Chemie (8IX) |
Sequence modifications
C: 2 - 340 (UniProt: P62873)
R: -115 - -10 (UniProt: P0ABE7)
R: 2 - 322 (UniProt: Q96LA9)
PDB | External Database | Details |
---|---|---|
Met -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -149 | - | expression tag |
Tyr -148 | - | expression tag |
Lys -147 | - | expression tag |
Asp -146 | - | expression tag |
Asp -145 | - | expression tag |
Asp -144 | - | expression tag |
Asp -143 | - | expression tag |
Ala -142 | - | expression tag |
Lys -141 | - | expression tag |
Leu -140 | - | expression tag |
Gln -139 | - | expression tag |
Thr -138 | - | expression tag |
Met -137 | - | expression tag |
His -136 | - | expression tag |
His -135 | - | expression tag |
His -134 | - | expression tag |
His -133 | - | expression tag |
His -132 | - | expression tag |
His -131 | - | expression tag |
His -130 | - | expression tag |
His -129 | - | expression tag |
His -128 | - | expression tag |
His -127 | - | expression tag |
Glu -126 | - | expression tag |
Asn -125 | - | expression tag |
Leu -124 | - | expression tag |
Tyr -123 | - | expression tag |
Phe -122 | - | expression tag |
Gln -121 | - | expression tag |
Gly -120 | - | expression tag |
Gly -119 | - | expression tag |
Thr -118 | - | expression tag |
Thr -117 | - | expression tag |
Met -116 | - | expression tag |
Trp -109 | Met 29 | engineered mutation |
Ile -14 | His 124 | engineered mutation |
Leu -10 | Arg 128 | engineered mutation |
Gly -9 | - | insertion |
Ser -8 | - | insertion |
Thr -7 | - | insertion |
Leu -6 | - | insertion |
Glu -5 | - | insertion |
Val -4 | - | insertion |
Leu -3 | - | insertion |
Phe -2 | - | insertion |
Gln -1 | - | insertion |
Gly 0 | - | insertion |
Pro 1 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 157455.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 355.5 | |
All* | Total formula weight | 157810.6 |