4RWD

XFEL structure of the human delta opioid receptor in complex with a bifunctional peptide

Summary for 4RWD

Related4N6H 4EJ4 4RWA
Related PRD IDPRD_001256
DescriptorSoluble cytochrome b562,Delta-type opioid receptor, bifunctional peptide, OLEIC ACID, ... (6 entities in total)
Functional Keywordshuman opioid receptor, bifunctional peptide, gpcr signaling, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, lipidic cubic phase, x-ray free-electron laser, serial femtosecond crystallography, bril
Biological sourceEscherichia coli
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Total number of polymer chains4
Total molecular weight95688.01
Authors
Primary citation
Fenalti, G.,Zatsepin, N.A.,Betti, C.,Giguere, P.,Han, G.W.,Ishchenko, A.,Liu, W.,Guillemyn, K.,Zhang, H.,James, D.,Wang, D.,Weierstall, U.,Spence, J.C.,Boutet, S.,Messerschmidt, M.,Williams, G.J.,Gati, C.,Yefanov, O.M.,White, T.A.,Oberthuer, D.,Metz, M.,Yoon, C.H.,Barty, A.,Chapman, H.N.,Basu, S.,Coe, J.,Conrad, C.E.,Fromme, R.,Fromme, P.,Tourwe, D.,Schiller, P.W.,Roth, B.L.,Ballet, S.,Katritch, V.,Stevens, R.C.,Cherezov, V.
Structural basis for bifunctional peptide recognition at human delta-opioid receptor.
Nat.Struct.Mol.Biol., 22:265-268, 2015
PubMed: 25686086 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2965
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.237103.2%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4rwd
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Molmil generated image of 4rwd
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Molmil generated image of 4rwd
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More Biological unit images

Molmil generated image of 4rwd
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Molmil generated image of 4rwd
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Molmil generated image of 4rwd
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4rwd.pdb1.gz [131.02 KB])
Coordinate files for Biological unit (4rwd.pdb2.gz [130.89 KB])