4S0V

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant

Replaces:  4RNB

Summary for 4S0V

DescriptorHuman Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID, ... (4 entities in total)
Functional Keywordsg protein-coupled receptor, orexin neurotransmitters, orexin receptor, orexin-a, orexin-b, suvorexant, n-linked glycosylation, signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane ; Multi- pass membrane protein  O43614
Total number of polymer chains1
Total molecular weight64823.16
Authors
Yin, J.,Kolb, P.,Mobarec, J.C.,Rosenbaum, D.M. (deposition date: 2015-01-06, release date: 2015-01-14, Last modification date: 2017-08-23)
Primary citation
Yin, J.,Mobarec, J.C.,Kolb, P.,Rosenbaum, D.M.
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Nature, 519:247-250, 2015
PubMed: 25533960 (PDB entries with the same primary citation)
DOI: 10.1038/nature14035
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244200.2%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload