4S0V

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant

Replaces:  4RNB

Summary for 4S0V

• Entry DOI: 10.2210/pdb4s0v/pdb
• Descriptor: Human Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID, ... (4 entities in total)
• Functional Keywords: g protein-coupled receptor, orexin neurotransmitters, orexin receptor, orexin-a, orexin-b, suvorexant, n-linked glycosylation, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane ; Multi- pass membrane protein : O43614
• Total number of polymer chains: 1
• Total formula weight: 64823.16

Authors

Yin, J.,Kolb, P.,Mobarec, J.C.,Rosenbaum, D.M. (deposition date: 2015-01-06, release date: 2015-01-14, Last modification date: 2023-09-20)

• Primary citation: Yin, J.,Mobarec, J.C.,Kolb, P.,Rosenbaum, D.M.; Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.; Nature, 519:247-250, 2015; PubMed: 25533960; DOI: 10.1038/nature14035

Experimental method

X-RAY DIFFRACTION (2.5 Å)