4S0V

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant

Replaces:  4RNB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007631	biological_process	feeding behavior
A	0016020	cellular_component	membrane
A	0016499	molecular_function	orexin receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SUV A 2001

Chain	Residue
A	THR111
A	ILE320
A	ASN324
A	HOH4025
A	VAL114
A	TRP120
A	ILE130
A	PRO131
A	GLN134
A	THR135
A	GLN187
A	GLU212

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Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSVlTLSCIALDRWYaI

Chain	Residue	Details
A	VAL140-ILE156

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TRP55-VAL75

---

site_id	SWS_FT_FI2
Number of Residues	31
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	CYS76-VAL88
A	ASP151-ARG170

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	THR89-ALA110

---

site_id	SWS_FT_FI4
Number of Residues	61
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	THR111-CYS127
A	GLU192-MET222
A	LYS327-VAL342

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	LYS128-LEU150

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	ASN171-MET191

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TYR223-TYR243

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	MET305-LEU326

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TYR343-PHE366

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25533960, ECO:0007744|PDB:4S0V

Chain	Residue	Details
A	ASN324

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	SITE: Important for responses to orexin => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	TRP44

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site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN14
A	ASN22
A	ASN202

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