4S0V
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant
Replaces: 4RNBEntity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Human Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase | polymer | 559 | 64089.8 | 1 | UniProt (O43614) UniProt (Q9V2J8) Pfam (PF00001) Pfam (PF13692) In PDB | Homo sapiens (human) | Ox-2-R, Ox2-R, Ox2R, Hypocretin receptor type 2, Glycogen synthase |
2 | A | [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone | non-polymer | 450.9 | 1 | Chemie (SUV) | |||
3 | A | OLEIC ACID | non-polymer | 282.5 | 1 | Chemie (OLA) | |||
4 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A: 3 - 254 (UniProt: O43614)
A: 1001 - 1196 (UniProt: Q9V2J8)
A: 294 - 388 (UniProt: O43614)
PDB | External Database | Details |
---|---|---|
Asp -5 | - | expression tag |
Tyr -4 | - | expression tag |
Lys -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Ala 1 | - | expression tag |
Met 2 | - | expression tag |
A: 294 - 388 (UniProt: O43614)
PDB | External Database | Details |
---|---|---|
His 389 | - | expression tag |
His 390 | - | expression tag |
His 391 | - | expression tag |
His 392 | - | expression tag |
His 393 | - | expression tag |
His 394 | - | expression tag |
His 395 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 64089.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 733.4 | |
All* | Total formula weight | 64823.2 |