PDB: 1573 件ウェブページステータス検索Chemie searchBIRD

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5GAK	Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A 分子名称: 25S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, 5.8S rRNA, ... 著者 Schmidt, C, Becker, T. 登録日 2015-12-09 公開日 2016-02-24 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome. Nucleic Acids Res., 44, 2016
5GJQ	Structure of the human 26S proteasome bound to USP14-UbAl 分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... 著者 Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. 登録日 2016-07-01 公開日 2016-08-17 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 An atomic structure of the human 26S proteasome. Nat. Struct. Mol. Biol., 23, 2016
5FLX	Mammalian 40S HCV-IRES complex 分子名称: 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... 著者 Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T. 登録日 2015-10-28 公開日 2015-12-23 最終更新日 2017-08-30 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA. Embo J., 34, 2015
3OJ4	Crystal structure of the A20 ZnF4, ubiquitin and UbcH5A complex 分子名称: Tumor necrosis factor alpha-induced protein 3, Ubiquitin, Ubiquitin-conjugating enzyme E2 D1, ... 著者 Bosanac, I, Hymowitz, S.G. 登録日 2010-08-20 公開日 2010-12-08 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling Mol.Cell, 40, 2010
6ZON	SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. 登録日 2020-07-07 公開日 2020-07-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
6ZP4	SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. 登録日 2020-07-08 公開日 2020-07-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science, 369, 2020
7ABF	Human pre-Bact-1 spliceosome core structure 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. 登録日 2020-09-07 公開日 2020-12-09 最終更新日 2020-12-30 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
6ZXE	Cryo-EM structure of a late human pre-40S ribosomal subunit - State F2 分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... 著者 Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R. 登録日 2020-07-29 公開日 2020-12-02 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis for the final steps of human 40S ribosome maturation. Nature, 587, 2020
7A09	Structure of a human ABCE1-bound 43S pre-initiation complex - State III 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Kratzat, H, Mackens-Kiani, T, Ameismeier, A, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. 登録日 2020-08-07 公開日 2020-10-14 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes. Embo J., 40, 2021
7ABG	Human pre-Bact-1 spliceosome 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ... 著者 Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. 登録日 2020-09-07 公開日 2020-12-23 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (7.8 Å) 主引用文献 Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
7ABI	Human pre-Bact-2 spliceosome 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... 著者 Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. 登録日 2020-09-07 公開日 2021-02-10 実験手法 ELECTRON MICROSCOPY (8 Å) 主引用文献 Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
6ZUO	Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage) 分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... 著者 Plassart, L, Shayan, R, Plisson-Chastang, C. 登録日 2020-07-23 公開日 2021-05-12 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. Elife, 10, 2021
6ZV6	Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) 分子名称: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... 著者 Plassart, L, Shayan, R, Plisson-Chastang, C. 登録日 2020-07-24 公開日 2021-05-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. Elife, 10, 2021
7M6T	Crystal structure of SOCS2/ElonginB/ElonginC bound to a non-canonical peptide that enhances phospho-peptide binding 分子名称: Elongin-B, Elongin-C, Non-canonical peptide F3, ... 著者 Kershaw, N.J, Li, K, Linossi, E.M, Nicholson, S.E. 登録日 2021-03-26 公開日 2021-10-13 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3.194 Å) 主引用文献 Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat Commun, 12, 2021
7M2K	CDC34A-Ubiquitin-2ab inhibitor complex 分子名称: 4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1 著者 Ceccarelli, D.F, St-Cyr, D, Tyers, M, Sicheri, F. 登録日 2021-03-16 公開日 2021-11-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex. Sci Adv, 7, 2021
7MEY	Structure of yeast Ubr1 in complex with Ubc2 and monoubiquitinated N-degron 分子名称: 2-(ethylamino)ethane-1-thiol, E3 ubiquitin-protein ligase UBR1, Monoubiquitinated N-degron, ... 著者 Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. 登録日 2021-04-08 公開日 2021-11-24 最終更新日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
7MEX	Structure of yeast Ubr1 in complex with Ubc2 and N-degron 分子名称: E3 ubiquitin-protein ligase UBR1, N-degron, Ubiquitin, ... 著者 Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. 登録日 2021-04-08 公開日 2021-11-24 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
7AI0	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Magnussen, H.M, Huang, D.T. 登録日 2020-09-25 公開日 2021-01-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.559 Å) 主引用文献 Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
7AI1	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 2) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Magnussen, H.M, Huang, D.T. 登録日 2020-09-25 公開日 2021-01-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
7AHZ	Crystal structure of Western clawed frog MDM2 RING domain homodimer bound to UbcH5B-Ub 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, ... 著者 Magnussen, H.M, Huang, D.T. 登録日 2020-09-25 公開日 2021-01-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
7B5N	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-UBE2L3~Ub~ARIH1. 分子名称: 5-azanylpentan-2-one, Cullin-1, E3 ubiquitin-protein ligase ARIH1, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-05 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7B5L	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 分子名称: 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-04 公開日 2021-02-10 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7B5M	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-p27~Ub~ARIH1. Transition State 2 分子名称: Cullin-1, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, ... 著者 Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. 登録日 2020-12-05 公開日 2021-02-17 最終更新日 2021-03-10 実験手法 ELECTRON MICROSCOPY (3.91 Å) 主引用文献 Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
7ASE	43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase 分子名称: 18S, 40S ribosomal protein S10, putative, ... 著者 Bochler, A, Brito Querido, J, Prilepskaja, T, Soufari, H, Del Cistia, M.L, Kuhn, L, Rimoldi Ribeiro, A, Valasek, L.S, Hashem, Y. 登録日 2020-10-27 公開日 2021-04-14 最終更新日 2021-04-21 実験手法 ELECTRON MICROSCOPY (3.33 Å) 主引用文献 Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts. Cell Rep, 33, 2020
7AZY	Context-specific inhibition of eukaryotic translation by macrolide antibiotics 分子名称: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Koller, T.O, Wilson, D.N. 登録日 2020-11-17 公開日 2021-05-19 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.877 Å) 主引用文献 Context-specific action of macrolide antibiotics on the eukaryotic ribosome. Nat Commun, 12, 2021

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