7B5L

Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1

Summary for 7B5L

Entry DOI	10.2210/pdb7b5l/pdb
EMDB information	12004 12005 12006 12007 12037
Descriptor	Cullin-1, Cyclin-dependent kinase 2, Cyclin-A2, ... (14 entities in total)
Functional Keywords	ubiquitin, ubiquitin ligase, e3 ligase, f-box protein, rbr ligase, cullin-ring-ligase, crl, scf, nedd8, post-translational modification, ubiquitylation, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	382217.52
Authors	Horn-Ghetko, D.,Prabu, J.R.,Schulman, B.A. (deposition date: 2020-12-04, release date: 2021-02-10, Last modification date: 2021-03-10)
Primary citation	Horn-Ghetko, D.,Krist, D.T.,Prabu, J.R.,Baek, K.,Mulder, M.P.C.,Klugel, M.,Scott, D.C.,Ovaa, H.,Kleiger, G.,Schulman, B.A. Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590:671-676, 2021 Cited by PubMed: 33536622 DOI: 10.1038/s41586-021-03197-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation