7B5L
Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1
Summary for 7B5L
Entry DOI | 10.2210/pdb7b5l/pdb |
EMDB information | 12004 12005 12006 12007 12037 |
Descriptor | Cullin-1, Cyclin-dependent kinase 2, Cyclin-A2, ... (14 entities in total) |
Functional Keywords | ubiquitin, ubiquitin ligase, e3 ligase, f-box protein, rbr ligase, cullin-ring-ligase, crl, scf, nedd8, post-translational modification, ubiquitylation, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 382217.52 |
Authors | Horn-Ghetko, D.,Prabu, J.R.,Schulman, B.A. (deposition date: 2020-12-04, release date: 2021-02-10, Last modification date: 2021-03-10) |
Primary citation | Horn-Ghetko, D.,Krist, D.T.,Prabu, J.R.,Baek, K.,Mulder, M.P.C.,Klugel, M.,Scott, D.C.,Ovaa, H.,Kleiger, G.,Schulman, B.A. Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590:671-676, 2021 Cited by PubMed: 33536622DOI: 10.1038/s41586-021-03197-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.8 Å) |
Structure validation
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