SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1

This is a large structure.

Summary for 6ZON

EMDB information11276 11325
Descriptor40S ribosomal protein SA, 40S ribosomal protein S3a, 40S ribosomal protein S2, ... (49 entities in total)
Functional Keywordstranslational inhibition, sars-cov-2, immune evasion, human ribosome, viral protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains48
Total molecular weight1894016.8
Primary citation
Thoms, M.,Buschauer, R.,Ameismeier, M.,Koepke, L.,Denk, T.,Hirschenberger, M.,Kratzat, H.,Hayn, M.,Mackens-Kiani, T.,Cheng, J.,Straub, J.H.,Sturzel, C.M.,Frohlich, T.,Berninghausen, O.,Becker, T.,Kirchhoff, F.,Sparrer, K.M.J.,Beckmann, R.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 2020
PubMed: 32680882 (PDB entries with the same primary citation)
DOI: 10.1126/science.abc8665
MImport into Mendeley
Experimental method

Structure validation

Ramachandran outliersSidechain outliersRNA backbone 0.0% 0.8% 0.45MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
PDB entries from 2020-08-12