6ZON

SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1

This is a large structure.

Summary for 6ZON

EMDB information11276 11325
Descriptor40S ribosomal protein SA, 40S ribosomal protein S3a, 40S ribosomal protein S2, ... (49 entities in total)
Functional Keywordstranslational inhibition, sars-cov-2, immune evasion, human ribosome, viral protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains48
Total molecular weight1894016.8
Authors
Primary citation
Thoms, M.,Buschauer, R.,Ameismeier, M.,Koepke, L.,Denk, T.,Hirschenberger, M.,Kratzat, H.,Hayn, M.,Mackens-Kiani, T.,Cheng, J.,Straub, J.H.,Sturzel, C.M.,Frohlich, T.,Berninghausen, O.,Becker, T.,Kirchhoff, F.,Sparrer, K.M.J.,Beckmann, R.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 2020
PubMed: 32680882 (PDB entries with the same primary citation)
DOI: 10.1126/science.abc8665
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
?

Structure validation

Ramachandran outliersSidechain outliersRNA backbone 0.0% 0.8% 0.45MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation reportDownload
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PDB entries from 2020-08-12