7M2K

CDC34A-Ubiquitin-2ab inhibitor complex

Summary for 7M2K

• Entry DOI: 10.2210/pdb7m2k/pdb
• Descriptor: Ubiquitin-conjugating enzyme E2 R1, Ubiquitin, 4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide, ... (4 entities in total)
• Functional Keywords: ubiquitin, ube2r1, ubiquitin conjugating enzyme, inhibitor, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 119427.07

Authors

Ceccarelli, D.F.,St-Cyr, D.,Tyers, M.,Sicheri, F. (deposition date: 2021-03-16, release date: 2021-11-03, Last modification date: 2023-10-18)

• Primary citation: St-Cyr, D.,Ceccarelli, D.F.,Orlicky, S.,van der Sloot, A.M.,Tang, X.,Kelso, S.,Moore, S.,James, C.,Posternak, G.,Coulombe-Huntington, J.,Bertomeu, T.,Marinier, A.,Sicheri, F.,Tyers, M.; Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.; Sci Adv, 7:eabi5797-eabi5797, 2021; PubMed: 34705497; DOI: 10.1126/sciadv.abi5797

Experimental method

X-RAY DIFFRACTION (2.47 Å)