7M2K

CDC34A-Ubiquitin-2ab inhibitor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Ubiquitin-conjugating enzyme E2 R1	polymer	180	20500.2	4	UniProt (P49427) Pfam (PF00179)	Homo sapiens (Human)	(E3-independent) E2 ubiquitin-conjugating enzyme R1,E2 ubiquitin-conjugating enzyme R1,Ubiquitin-conjugating enzyme E2-32 kDa complementing,Ubiquitin-conjugating enzyme E2-CDC34,Ubiquitin-protein ligase R1
2	B, D, F, H (B, D, F, H)	Ubiquitin	polymer	80	8893.2	4	UniProt (P0CG47) Pfam (PF00240)	Homo sapiens (Human)
3	I, J, K, L (A, C, E, G)	4-[(3',5'-dichloro[1,1'-biphenyl]-4-yl)methyl]-N-ethyl-1-(methoxyacetyl)piperidine-4-carboxamide	non-polymer		463.4	4	Chemie (GZM)
4	M, N, O, P, Q... (A, B, C, E, F...)	water	water		18.0	27	Chemie (HOH)

Sequence modifications

A, C, E, G: 7 - 184 (UniProt: P49427)

PDB	External Database	Details
Gly 5	-	expression tag
Ser 6	-	expression tag

B, D, F, H: 1 - 76 (UniProt: P0CG47)

PDB	External Database	Details
Gly -3	-	expression tag
Ala -2	-	expression tag
Met -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	117573.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1853.6
All*	Total formula weight	119427.1

*Water molecules are not included.