7M6T

Crystal structure of SOCS2/ElonginB/ElonginC bound to a non-canonical peptide that enhances phospho-peptide binding

Summary for 7M6T

Entry DOI	10.2210/pdb7m6t/pdb
Descriptor	Suppressor of cytokine signaling 2, Elongin-B, Elongin-C, ... (6 entities in total)
Functional Keywords	sh2, e3 ligase, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	45010.19
Authors	Kershaw, N.J.,Li, K.,Linossi, E.M.,Nicholson, S.E. (deposition date: 2021-03-26, release date: 2021-10-13, Last modification date: 2023-10-18)
Primary citation	Linossi, E.M.,Li, K.,Veggiani, G.,Tan, C.,Dehkhoda, F.,Hockings, C.,Calleja, D.J.,Keating, N.,Feltham, R.,Brooks, A.J.,Li, S.S.,Sidhu, S.S.,Babon, J.J.,Kershaw, N.J.,Nicholson, S.E. Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat Commun, 12:7032-7032, 2021 Cited by PubMed: 34857742 DOI: 10.1038/s41467-021-26983-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.194 Å)

Structure validation