7M6T
Crystal structure of SOCS2/ElonginB/ElonginC bound to a non-canonical peptide that enhances phospho-peptide binding
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Suppressor of cytokine signaling 2 | polymer | 170 | 19342.1 | 1 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) | Homo sapiens (Human) | SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2 |
| 2 | B (B) | Elongin-B | polymer | 118 | 13251.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C (C) | Elongin-C | polymer | 96 | 10843.4 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (Human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 4 | D (D) | Non-canonical peptide F3 | polymer | 12 | 1476.8 | 1 | synthetic construct | ||
| 5 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | F (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 32 - 198 (UniProt: O14508)
| PDB | External Database | Details |
|---|---|---|
| Ala 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Gln 31 | - | expression tag |
| Ala 115 | Lys 115 | engineered mutation |
| Ala 117 | Lys 117 | engineered mutation |
| Ala 118 | Gln 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 44914.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 96.1 | |
| All* | Total formula weight | 45010.2 |
