5JWA
 
 | | the structure of malaria PfNDH2 | | Descriptor: | ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, FRAGMENT OF TRITON X-100, ... | | Authors: | Yu, Y, Yang, Y.Q, Li, X.L, Yu, J, Ge, J.P, Li, J, Rao, Y, Yang, M.J. | | Deposit date: | 2016-05-11 | | Release date: | 2017-03-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.162 Å) | | Cite: | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
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5JWB
 | | Structure of NDH2 from plasmodium falciparum in complex with NADH | | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Yu, Y, Li, X.L. | | Deposit date: | 2016-05-12 | | Release date: | 2017-03-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
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5JWC
 | | Structure of NDH2 from plasmodium falciparum in complex with RYL-552 | | Descriptor: | 5-fluoro-3-methyl-2-{4-[4-(trifluoromethoxy)benzyl]phenyl}quinolin-4(1H)-one, FLAVIN-ADENINE DINUCLEOTIDE, FRAGMENT OF TRITON X-100, ... | | Authors: | Yu, Y. | | Deposit date: | 2016-05-12 | | Release date: | 2017-03-22 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.051 Å) | | Cite: | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria
J. Med. Chem., 60, 2017
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8T64
 | | Apo Cam1(42-206) | | Descriptor: | Cam1 | | Authors: | Yu, Y, Patel, D.J. | | Deposit date: | 2023-06-15 | | Release date: | 2024-01-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The CRISPR effector Cam1 mediates membrane depolarization for phage defence.
Nature, 625, 2024
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8T65
 | | cA4 bound Cam1 | | Descriptor: | Cam1, RNA (5'-R(P*AP*AP*AP*A)-3') | | Authors: | Yu, Y, Patel, D.J. | | Deposit date: | 2023-06-15 | | Release date: | 2024-01-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | The CRISPR effector Cam1 mediates membrane depolarization for phage defence.
Nature, 625, 2024
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8T66
 | | cA6 bound Cam1 | | Descriptor: | Cam1, RNA (5'-R(P*AP*AP*AP*AP*A)-3') | | Authors: | Yu, Y, Patel, D.J. | | Deposit date: | 2023-06-15 | | Release date: | 2024-01-10 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The CRISPR effector Cam1 mediates membrane depolarization for phage defence.
Nature, 625, 2024
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1O5T
 | | Crystal structure of the aminoacylation catalytic fragment of human tryptophanyl-tRNA synthetase | | Descriptor: | Tryptophanyl-tRNA synthetase | | Authors: | Yu, Y, Liu, Y, Shen, N, Xu, X, Jia, J, Jin, Y, Arnold, E, Ding, J. | | Deposit date: | 2003-10-05 | | Release date: | 2004-07-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of Human Tryptophanyl-tRNA Synthetase Catalytic Fragment
J.BIOL.CHEM., 279, 2004
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7VYU
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8T8E
 | | cryoEM structure of Smc5/6 5mer | | Descriptor: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 5, Structural maintenance of chromosomes protein 6 | | Authors: | Yu, Y, Patel, D.J. | | Deposit date: | 2023-06-22 | | Release date: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8T8F
 | | Smc5/6 8mer | | Descriptor: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 4, Non-structural maintenance of chromosome element 5, ... | | Authors: | Yu, Y, Patel, D.J. | | Deposit date: | 2023-06-22 | | Release date: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions.
Proc.Natl.Acad.Sci.USA, 120, 2023
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1XTQ
 | | Structure of small GTPase human Rheb in complex with GDP | | Descriptor: | GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Yu, Y, Ding, J. | | Deposit date: | 2004-10-24 | | Release date: | 2005-03-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
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1XTS
 | | Structure of small GTPase human Rheb in complex with GTP | | Descriptor: | GTP-binding protein Rheb, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | Authors: | Yu, Y, Ding, J. | | Deposit date: | 2004-10-24 | | Release date: | 2005-03-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis for the Unique Biological Function of Small GTPase RHEB
J.Biol.Chem., 280, 2005
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1XTR
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7SDE
 | | Cryo-EM structure of Nse5/6 heterodimer | | Descriptor: | Non-structural maintenance of chromosome element 5, Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera | | Authors: | Yu, Y, Patel, D.J, Zhao, X.L. | | Deposit date: | 2021-09-29 | | Release date: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The cryo-EM structure of Nse5/6 complex with the C terminal part of Nse5
To Be Published
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4B2H
 | | COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS | | Descriptor: | 3-[7,8-dimethyl-2,4-bis(oxidanylidene)benzo[g]pteridin-10-yl]propylcarbamic acid, CHLORIDE ION, DODECIN, ... | | Authors: | Yu, Y, Heidel, B, Parapugna, T.L, Wenderhold-Reeb, S, Song, B, Schoenherr, H, Grininger, M, Noell, G. | | Deposit date: | 2012-07-16 | | Release date: | 2013-05-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The Flavoprotein Dodecin as a Redox Probe for Electron Transfer Through DNA.
Angew.Chem.Int.Ed.Engl., 52, 2013
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7YIW
 | | The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (ALPL) at Acidic pH | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | | Authors: | Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Cao, Y. | | Deposit date: | 2022-07-18 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
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7YIX
 | | The Cryo-EM Structure of Human Tissue Nonspecific Alkaline Phosphatase and Single-Chain Fragment Variable (ScFv) Complex. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkaline phosphatase, ... | | Authors: | Yu, Y.T, Yao, D.Q, Zhang, Q, Rao, B, Xia, Y, Lu, Y, Qin, A, Ma, P.X, Cao, Y. | | Deposit date: | 2022-07-18 | | Release date: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Nat Commun, 14, 2023
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3HRO
 | | Crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2, polycystic kidney disease 2) | | Descriptor: | Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2), also called Polycystin-2 or polycystic kidney disease 2(PKD2) | | Authors: | Yu, Y, Ulbrich, M.H, Li, M.-H, Buraei, Z, Chen, X.-Z, Ong, A.C.M, Tong, L, Isacoff, E.Y, Yang, J. | | Deposit date: | 2009-06-09 | | Release date: | 2009-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3HRN
 | | crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2, polycystic kidney disease 2) | | Descriptor: | Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2) | | Authors: | Yu, Y, Ulbrich, M.H, Li, M.-H, Buraei, Z, Chen, X.-Z, Ong, A.C.M, Tong, L, Isacoff, E.Y, Yang, J. | | Deposit date: | 2009-06-09 | | Release date: | 2009-07-28 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Proc.Natl.Acad.Sci.USA, 106, 2009
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5XHS
 | | Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA | | Descriptor: | (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, 7-AMINO-4-METHYL-CHROMEN-2-ONE, NAD-dependent protein deacylase sirtuin-5, ... | | Authors: | Yu, Y, Li, B, Chen, Q. | | Deposit date: | 2017-04-24 | | Release date: | 2018-05-02 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design
Rsc Adv, 7, 2017
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2G3F
 | | Crystal Structure of imidazolonepropionase complexed with imidazole-4-acetic acid sodium salt, a substrate homologue | | Descriptor: | 2H-IMIDAZOL-4-YLACETIC ACID, Imidazolonepropionase, ZINC ION | | Authors: | Yu, Y, Liang, Y.H, Su, X.D. | | Deposit date: | 2006-02-19 | | Release date: | 2006-09-26 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis
J.Biol.Chem., 281, 2006
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3IPM
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2FKN
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4GIF
 | | C-terminal coiled-coil domain of transient receptor potential channel TRPP3 (PKD2L1, Polycystin-L) | | Descriptor: | Polycystic kidney disease 2-like 1 protein | | Authors: | Yu, Y, Ulbrich, M.H, Li, M.-H, Dobbins, S, Zhang, W.K, Tong, L, Isacoff, E.Y, Yang, J. | | Deposit date: | 2012-08-08 | | Release date: | 2012-12-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex.
Nat Commun, 3, 2012
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3V4V
 | | crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376 | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Yu, Y, Zhu, J, Springer, T.A. | | Deposit date: | 2011-12-15 | | Release date: | 2012-01-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196, 2012
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