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5XHS

Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA

Summary for 5XHS
Entry DOI10.2210/pdb5xhs/pdb
DescriptorNAD-dependent protein deacylase sirtuin-5, mitochondrial, benzyl chlorocarbonate, (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, ... (6 entities in total)
Functional Keywordssirtuin, fluorogenic small molecule substrates, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationMitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion : Q9NXA8
Total number of polymer chains1
Total formula weight32111.14
Authors
Yu, Y.,Li, B.,Chen, Q. (deposition date: 2017-04-24, release date: 2018-05-02, Last modification date: 2024-03-27)
Primary citationWang, H.L.,Liu, S.,Yu, Z.J.,Wu, C.,Cheng, L.,Wang, Y.,Chen, K.,Zhou, S.,Chen, Q.,Yu, Y.,Li, G.B.
Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design
Rsc Adv, 7:36214-36222, 2017
Cited by
DOI: 10.1039/C7RA05824A
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.19 Å)
Structure validation

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