5XHS
Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 404 |
| Chain | Residue |
| A | CYS166 |
| A | CYS169 |
| A | CYS207 |
| A | CYS212 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residues PHQ A 401 and SLL A 402 |
| Chain | Residue |
| A | TRP222 |
| A | PHE223 |
| A | GLY224 |
| A | LEU232 |
| A | ASP236 |
| A | TYR255 |
| A | PHE260 |
| A | MCM403 |
| A | MCM403 |
| A | TYR102 |
| A | ARG105 |
| A | ILE142 |
| A | HIS158 |
| A | VAL221 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residues SLL A 402 and MCM A 403 |
| Chain | Residue |
| A | TYR102 |
| A | ARG105 |
| A | ILE142 |
| A | HIS158 |
| A | VAL221 |
| A | TRP222 |
| A | GLU225 |
| A | ASN226 |
| A | LEU227 |
| A | LEU232 |
| A | TYR255 |
| A | MET259 |
| A | PHQ401 |
| A | PHQ401 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:29180469 |
| Chain | Residue | Details |
| A | HIS158 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:22767592, ECO:0000269|Ref.19 |
| Chain | Residue | Details |
| A | GLY58 | |
| A | GLN140 | |
| A | GLY249 | |
| A | ASN275 | |
| A | CYS293 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
| Chain | Residue | Details |
| A | TYR102 | |
| A | ARG105 | |
| A | CYS166 | |
| A | CYS169 | |
| A | CYS207 | |
| A | CYS212 |
