5JWC

Structure of NDH2 from plasmodium falciparum in complex with RYL-552

Summary for 5JWC

Entry DOI	10.2210/pdb5jwc/pdb
Related	5JWA 5JWB
Descriptor	NADH dehydrogenase, putative, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	pfndh2, ndh2, plasmodium falciparum, malaria, inhibitor, membrane protein
Biological source	Plasmodium falciparum (isolate 3D7)
Total number of polymer chains	2
Total formula weight	126188.58
Authors	Yu, Y. (deposition date: 2016-05-12, release date: 2017-03-22, Last modification date: 2023-11-08)
Primary citation	Yang, Y.,Yu, Y.,Li, X.,Li, J.,Wu, Y.,Yu, J.,Ge, J.,Huang, Z.,Jiang, L.,Rao, Y.,Yang, M. Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem., 60:1994-2005, 2017 Cited by PubMed: 28195463 DOI: 10.1021/acs.jmedchem.6b01733 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.051 Å)

Structure validation