3V4V

crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376

Summary for 3V4V

Related3V4P
DescriptorIntegrin alpha-4, Integrin beta-7, MONOCLONAL ANTIBODY Act-1 HEAVY CHAIN, ... (11 entities in total)
Functional Keywordscell adhesion, madcam-1, membrane
Biological sourceHomo sapiens (human)
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Total number of polymer chains8
Total molecular weight342633.92
Authors
Yu, Y.,Zhu, J.,Springer, T.A. (deposition date: 2011-12-15, release date: 2012-01-11, Last modification date: 2020-07-29)
Primary citation
Yu, Y.,Zhu, J.,Mi, L.Z.,Walz, T.,Sun, H.,Chen, J.,Springer, T.A.
Structural specializations of a4b7, an Integrin that Mediates Rolling Adhesion
J.Cell Biol., 196:131-146, 2012
PubMed: 22232704 (PDB entries with the same primary citation)
DOI: 10.1083/jcb.201110023
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2288 0.9% 1.7% 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-11-25