3V4V

crystal structure of a4b7 headpiece complexed with Fab ACT-1 and RO0505376

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007155	biological_process	cell adhesion
A	0008305	cellular_component	integrin complex
C	0007155	biological_process	cell adhesion
C	0008305	cellular_component	integrin complex

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR197-HIS203

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CsCapGrlGRlC

Chain	Residue	Details
B	CYS481-CYS492

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V

Chain	Residue	Details
A	ASP406
A	ASP408
A	ASN410
A	TYR412
A	ASP414
C	ASP281
C	ASN283
C	ASP285
C	ASP289
C	ASP344
C	ASP346
C	ASP348
C	ASP352
C	ASP406
C	ASP408
C	ASN410
C	TYR412
C	ASP414
B	SER142
B	SER144
D	SER142
D	SER144
A	ASP344
A	ASP346
A	ASP348
A	ASP352

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V

Chain	Residue	Details
B	ASP147
D	ASP147

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P

Chain	Residue	Details
B	ASP148
D	ASP148
A	ASN196
C	ASN46
C	ASN105
C	ASN196

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site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: in LIMBS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V

Chain	Residue	Details
B	ASP179
B	ASN235
B	ASP237
B	PRO239
D	ASP179
D	ASN235
D	ASP237
D	PRO239

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site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: in MIDAS binding site => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V

Chain	Residue	Details
B	GLU240
D	GLU240

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site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: in ADMIDAS binding site and liganded-open conformation => ECO:0000250|UniProtKB:P05107

Chain	Residue	Details
B	ASP270
D	ASP270

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site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V

Chain	Residue	Details
B	GLU354
D	GLU354

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site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN49
B	ASN458
D	ASN49
D	ASN458

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4P, ECO:0007744|PDB:3V4V

Chain	Residue	Details
B	ASN260
D	ASN260

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site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22232704, ECO:0007744|PDB:3V4V

Chain	Residue	Details
B	ASN415
D	ASN415

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