7XTQ
 
 | | Cryo-EM structure of the R399-bound GPBAR-Gs complex | | 分子名称: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | | 登録日 | 2022-05-17 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-03 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7XV3
 | | Cryo-EM structure of LPS-bound GPR174 in complex with Gs protein | | 分子名称: | (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid, Engineered G protein subunit S (mini-Gs), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | He, Y, Liang, J. | | 登録日 | 2022-05-20 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-03-08 | | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | | 主引用文献 | Structural basis of lysophosphatidylserine receptor GPR174 ligand recognition and activation.
Nat Commun, 14, 2023
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7XW6
 | | TSHR-Gs-M22 antibody-ML109 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | | 登録日 | 2022-05-26 | | 公開日 | 2022-08-17 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | | 主引用文献 | Hormone- and antibody-mediated activation of the thyrotropin receptor.
Nature, 609, 2022
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7XW5
 | | TSHR-thyroid stimulating hormone-Gs-ML109 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Glycoprotein hormones alpha chain, ... | | 著者 | Duan, J, Xu, P, Luan, X, Ji, Y, Yuan, Q, He, X, Ye, J, Cheng, X, Jiang, H, Zhang, S, Jiang, Y, Xu, H.E. | | 登録日 | 2022-05-26 | | 公開日 | 2022-08-24 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Hormone- and antibody-mediated activation of the thyrotropin receptor.
Nature, 609, 2022
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7XW9
 | | Cryo-EM structure of the TRH-bound human TRHR-Gq complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | 著者 | Ji, S, Dong, Y, Chen, L, Zang, S, Shen, D, Guo, J, Qin, J, Zhang, H, Wang, W, Shen, Q, Mao, C, Zhang, Y. | | 登録日 | 2022-05-26 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular basis for the activation of thyrotropin-releasing hormone receptor.
Cell Discov, 8, 2022
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7XWO
 | | Neurokinin A bound to active human neurokinin 2 receptor in complex with G324 | | 分子名称: | G324, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Sun, W.J, Yuan, Q.N, Zhang, H.H, Yang, F, Ling, S.L, Lv, P, Eric, X, Tian, C.L, Yin, W.C, Shi, P. | | 登録日 | 2022-05-26 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural insights into the activation of neurokinin 2 receptor by neurokinin A.
Cell Discov, 8, 2022
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7XXH
 | | Cryo-EM structure of the purinergic receptor P2Y1R in complex with 2MeSADP and G11 | | 分子名称: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(11) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-05-30 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023
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7XXI
 | | Cryo-EM structure of the purinergic receptor P2Y12R in complex with 2MeSADP and Gi | | 分子名称: | 2-(methylsulfanyl)adenosine 5'-(trihydrogen diphosphate), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Tan, Q, Li, B, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-05-30 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into signal transduction of the purinergic receptors P2Y1R and P2Y12R.
Protein Cell, 14, 2023
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7XY7
 | | Adenosine receptor bound to a non-selective agonist in complex with a G protein obtained by cryo-EM | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | | 登録日 | 2022-05-31 | | 公開日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex.
Sci Adv, 8, 2022
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7XY6
 | | Adenosine receptor bound to an agonist in complex with G protein obtained by cryo-EM | | 分子名称: | 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhang, J.Y, Chen, Y, Hua, T, Song, G.J. | | 登録日 | 2022-05-31 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Cryo-EM structure of the human adenosine A 2B receptor-G s signaling complex.
Sci Adv, 8, 2022
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7XZ5
 | | GPR119-Gs-LPC complex | | 分子名称: | (4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | | 登録日 | 2022-06-02 | | 公開日 | 2022-08-24 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.
Nat.Struct.Mol.Biol., 29, 2022
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7XZ6
 | | GPR119-Gs-APD668 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Xu, P, Huang, S, Jiang, Y, Xu, H.E. | | 登録日 | 2022-06-02 | | 公開日 | 2022-08-24 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.
Nat.Struct.Mol.Biol., 29, 2022
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7Y15
 | | Cryo-EM structure of apo-state MrgD-Gi complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | | 登録日 | 2022-06-06 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
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7Y12
 | | Cryo-EM structure of MrgD-Gi complex with beta-alanine | | 分子名称: | BETA-ALANINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Suzuki, S, Iida, M, Kawamoto, A, Oshima, A. | | 登録日 | 2022-06-06 | | 公開日 | 2022-07-20 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM.
Commun Biol, 5, 2022
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7Y1F
 | | Cryo-EM structure of human k-opioid receptor-Gi complex | | 分子名称: | Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Chen, B.O, Xu, F.E. | | 登録日 | 2022-06-08 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-06-21 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structure of human kappa-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A.
Protein Cell, 14, 2023
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7Y35
 | | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | | 分子名称: | Abaloparatide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | | 登録日 | 2022-06-09 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex
To Be Published
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7Y26
 | | Cryo-EM structure of the octreotide-bound SSTR2-miniGq-scFv16 complex | | 分子名称: | Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Chen, S, Zheng, S. | | 登録日 | 2022-06-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
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7Y27
 | | Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex | | 分子名称: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Chen, S, Zheng, S. | | 登録日 | 2022-06-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
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7Y24
 | | Cryo-EM structure of the octreotide-bound SSTR2-miniGo-scFv16 complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | | 著者 | Chen, S, Zheng, S. | | 登録日 | 2022-06-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-02-15 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Molecular basis for the selective G protein signaling of somatostatin receptors.
Nat.Chem.Biol., 19, 2023
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7Y36
 | | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HYDROXIDE ION, ... | | 著者 | Zhai, X, Mao, C, Shen, Q, Zang, S, Shen, D, Zhang, H, Chen, Z, Wang, G, Zhang, C, Zhang, Y, Liu, Z. | | 登録日 | 2022-06-10 | | 公開日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex
to be published
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7Y3G
 | | Cryo-EM structure of a class A orphan GPCR | | 分子名称: | G-protein coupled receptor 12, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, Z.J, Hua, T, Li, H, Zhang, J.Y, Luo, F. | | 登録日 | 2022-06-10 | | 公開日 | 2023-06-07 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structural insight into the constitutive activity of human orphan receptor GPR12.
Sci Bull (Beijing), 68, 2023
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8DCS
 | | Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | | 分子名称: | 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | | 登録日 | 2022-06-17 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies.
Nat Commun, 13, 2022
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8DCR
 | | Cryo-EM structure of dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein | | 分子名称: | DOBUTAMINE, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. | | 登録日 | 2022-06-17 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies.
Nat Commun, 13, 2022
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7Y64
 | | Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein | | 分子名称: | C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | 登録日 | 2022-06-18 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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7Y65
 | | Cryo-EM structure of C5a peptide-bound C5aR1 in complex with Gi protein | | 分子名称: | C5a anaphylatoxin chemotactic receptor 1, C5apep peptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Feng, Y.Y, Zhao, C, Yan, W, Shao, Z.H. | | 登録日 | 2022-06-18 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Mechanism of activation and biased signaling in complement receptor C5aR1.
Cell Res., 33, 2023
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