7XZ5

GPR119-Gs-LPC complex

Summary for 7XZ5

• Entry DOI: 10.2210/pdb7xz5/pdb
• EMDB information: 33525
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr, glucose-dependent insulinotropic receptor, gpr119, lysopc, lysophosphatidylcholine, g-protein, gs, signaling complex, structure-function relationships, membrane protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 161055.81

Authors

Xu, P.,Huang, S.,Jiang, Y.,Xu, H.E. (deposition date: 2022-06-02, release date: 2022-08-24, Last modification date: 2022-10-05)

• Primary citation: Xu, P.,Huang, S.,Guo, S.,Yun, Y.,Cheng, X.,He, X.,Cai, P.,Lan, Y.,Zhou, H.,Jiang, H.,Jiang, Y.,Xie, X.,Xu, H.E.; Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119.; Nat.Struct.Mol.Biol., 29:863-870, 2022; PubMed: 35970999; DOI: 10.1038/s41594-022-00816-5

Experimental method

ELECTRON MICROSCOPY (3.1 Å)