7Y67

Cryo-EM structure of C089-bound C5aR1(I116A) mutant in complex with Gi protein

Summary for 7Y67

• Entry DOI: 10.2210/pdb7y67/pdb
• EMDB information: 33636
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: complex, agonist, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 155460.26

Authors

Feng, Y.Y.,Zhao, C.,Yan, W.,Shao, Z.H. (deposition date: 2022-06-18, release date: 2023-03-01, Last modification date: 2023-04-19)

• Primary citation: Feng, Y.,Zhao, C.,Deng, Y.,Wang, H.,Ma, L.,Liu, S.,Tian, X.,Wang, B.,Bin, Y.,Chen, P.,Yan, W.,Fu, P.,Shao, Z.; Mechanism of activation and biased signaling in complement receptor C5aR1.; Cell Res., 33:312-324, 2023; PubMed: 36806352; DOI: 10.1038/s41422-023-00779-2

Experimental method

ELECTRON MICROSCOPY (2.8 Å)