7Y27

Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex

Summary for 7Y27

• Entry DOI: 10.2210/pdb7y27/pdb
• Related: 6WHA
• EMDB information: 33587
• Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, single Fab chain (svFv16), ... (7 entities in total)
• Functional Keywords: somatostatin receptor, g protein, biased ligand, gpcr, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 140227.30

Authors

Chen, S.,Zheng, S. (deposition date: 2022-06-09, release date: 2022-10-19, Last modification date: 2023-02-15)

• Primary citation: Chen, S.,Teng, X.,Zheng, S.; Molecular basis for the selective G protein signaling of somatostatin receptors.; Nat.Chem.Biol., 19:133-140, 2023; PubMed: 36138141; DOI: 10.1038/s41589-022-01130-3

Experimental method

ELECTRON MICROSCOPY (3.48 Å)