7Y27
Cryo-EM structure of the SST-14-bound SSTR2-miniGq-scFv16 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 338 | 37198.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | B (B) | Engineered Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 243 | 27809.5 | 1 | Homo sapiens | ||
| 3 | C (D) | single Fab chain (svFv16) | polymer | 258 | 27713.9 | 1 | Homo sapiens (human) | ||
| 4 | D (E) | Somatostatin receptor type 2 | polymer | 337 | 37759.8 | 1 | UniProt (P30874) Pfam (PF00001) | Homo sapiens (human) | SS-2-R,SS2-R,SS2R,SST2,SRIF-1 |
| 5 | E (F) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 6 | F (C) | somatostatin-14 | polymer | 12 | 1513.8 | 1 | Pfam (PF03002) UniProt (by SIFTS) (P61278) | Homo sapiens | |
| 7 | G (E) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
F: 1 - 71 (UniProt: P59768)
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 139840.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.7 | |
| All* | Total formula weight | 140227.3 |
