7XW9

Cryo-EM structure of the TRH-bound human TRHR-Gq complex

Summary for 7XW9

• Entry DOI: 10.2210/pdb7xw9/pdb
• EMDB information: 33494
• Related PRD ID: PRD_002371
• Descriptor: Thyrotropin-releasing hormone receptor, Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: trhr, trh, class a gpcr, biosynthetic protein, membrane protein, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 166897.86

Authors

Ji, S.,Dong, Y.,Chen, L.,Zang, S.,Shen, D.,Guo, J.,Qin, J.,Zhang, H.,Wang, W.,Shen, Q.,Mao, C.,Zhang, Y. (deposition date: 2022-05-26, release date: 2022-12-28, Last modification date: 2024-01-10)

• Primary citation: Ji, S.Y.,Dong, Y.J.,Chen, L.N.,Zang, S.K.,Wang, J.,Shen, D.D.,Guo, J.,Qin, J.,Zhang, H.,Wang, W.W.,Shen, Q.,Zhang, Y.,Song, Z.,Mao, C.; Molecular basis for the activation of thyrotropin-releasing hormone receptor.; Cell Discov, 8:116-116, 2022; PubMed: 36280665; DOI: 10.1038/s41421-022-00477-0

Experimental method

ELECTRON MICROSCOPY (2.7 Å)