7XW9
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Thyrotropin-releasing hormone receptor | polymer | 398 | 45119.7 | 1 | UniProt (P34981) Pfam (PF00001) | Homo sapiens (human) | TRH-R,Thyroliberin receptor |
| 2 | B (A) | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 409 | 46957.3 | 1 | Homo sapiens (human) | ||
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P54311) Pfam (PF00400) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 70 | 7729.9 | 1 | UniProt (P63212) Pfam (PF00631) | Bos taurus (cattle) | G gamma-I |
| 5 | E (S) | single Fab chain (svFv16) | polymer | 269 | 28813.0 | 1 | synthetic construct | ||
| 6 | F (L) | TRH peptide | polymer | 4 | 362.4 | 1 | BIRD (PRD_002371) | synthetic construct |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 166897.9 | |
| All* | Total formula weight | 166897.9 |
