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PDB: 61 件
2JBU
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Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.
分子名称: 1,4-DIETHYLENE DIOXIDE, CO-PURIFIED PEPTIDE, INSULIN-DEGRADING ENZYME
著者Im, H, Shen, Y, Tang, W.J.
登録日2006-12-11
公開日2007-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
2JG4
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Substrate-free IDE structure in its closed conformation
分子名称: 1,4-DIETHYLENE DIOXIDE, INSULIN DEGRADING ENZYME, ZINC ION
著者Malito, E, Tang, W.J.
登録日2007-02-07
公開日2007-07-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282, 2007
2G56
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crystal structure of human insulin-degrading enzyme in complex with insulin B chain
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin, Insulin-degrading enzyme
著者Shen, Y, Tang, W.-J.
登録日2006-02-22
公開日2006-10-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G54
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Crystal structure of Zn-bound human insulin-degrading enzyme in complex with insulin B chain
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, ZINC ION, ...
著者Shen, Y, Tang, W.-J.
登録日2006-02-22
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G48
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crystal structure of human insulin-degrading enzyme in complex with amylin
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, Islet amyloid polypeptide
著者Shen, Y, Tang, W.-J.
登録日2006-02-21
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
2G49
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BU of 2g49 by Molmil
Crystal structure of human insulin-degrading enzyme in complex with glucagon
分子名称: 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, glucagon preproprotein
著者Shen, Y, Tang, W.-J.
登録日2006-02-21
公開日2006-10-24
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Nature, 443, 2006
3E4Z
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BU of 3e4z by Molmil
Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II
分子名称: Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION
著者Guo, Q, Manolopoulou, M, Tang, W.-J.
登録日2008-08-12
公開日2009-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
3HGZ
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BU of 3hgz by Molmil
Crystal structure of human insulin-degrading enzyme in complex with amylin
分子名称: Insulin-degrading enzyme, Islet amyloid polypeptide, ZINC ION
著者Guo, Q, Bian, Y, Tang, W.J.
登録日2009-05-14
公開日2009-12-08
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.
J.Mol.Biol., 395, 2010
3CWW
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BU of 3cww by Molmil
Crystal Structure of IDE-bradykinin complex
分子名称: 1,4-DIETHYLENE DIOXIDE, ACETATE ION, Insulin-degrading enzyme, ...
著者Malito, E, Tang, W.J.
登録日2008-04-23
公開日2008-11-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Molecular Bases for the Recognition of Short Peptide Substrates and Cysteine-Directed Modifications of Human Insulin-Degrading Enzyme
Biochemistry, 47, 2008
5CJO
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Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FAB Heavy chain with engineered elbow, FAB light chain, ...
著者liang, w.g, bailey, L, tang, w.j.
登録日2015-07-14
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.287 Å)
主引用文献Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
2YPU
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human insulin degrading enzyme E111Q in complex with inhibitor compound 41367
分子名称: 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, INSULIN-DEGRADING ENZYME, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.-J.
登録日2012-11-01
公開日2012-11-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Imidazole-Derived 2-[N-Carbamoylmethyl-Alkylamino]Acetic Acids,Substrate-Dependent Modulators of Insulin-Degrading Enzyme in Amyloid-Beta Hydrolysis
Eur J Med Chem, 79C, 2014
6MQ3
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BU of 6mq3 by Molmil
Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocycle Inhibitor 63
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-degrading enzyme, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol
著者Tan, G.A, Seeliger, M.A, Welsh, A.J, Maianti, J.P, Liu, D.R.
登録日2018-10-09
公開日2019-04-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.569147 Å)
主引用文献Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat.Chem.Biol., 15, 2019
6EDS
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BU of 6eds by Molmil
Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Glucagon and Substrate-selective Macrocyclic Inhibitor 63
分子名称: 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ...
著者Tan, G.A, Seeliger, M.A, Maianti, J.P, Liu, D.R, Welsh, A.J.
登録日2018-08-10
公開日2019-04-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.18071723 Å)
主引用文献Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat.Chem.Biol., 15, 2019
3QZ2
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BU of 3qz2 by Molmil
The structure of cysteine-free human insulin degrading enzyme
分子名称: Insulin-degrading enzyme, ZINC ION
著者Guo, Q, Tang, W.J.
登録日2011-03-04
公開日2012-01-25
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4DTT
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BU of 4dtt by Molmil
Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367
分子名称: 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, Insulin-degrading enzyme, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-02-21
公開日2013-02-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
5UOE
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BU of 5uoe by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
分子名称: FAB Heavy chain with engineered elbow, FAB light chain, Insulin-degrading enzyme
著者Liang, W.G, Bailey, L, Kossiakoff, T, Tang, W.J.
登録日2017-01-31
公開日2018-02-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE)
To Be Published
4DWK
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BU of 4dwk by Molmil
Structure of cystein free insulin degrading enzyme with compound bdm41671 ((s)-2-{2-[carboxymethyl-(3-phenyl-propyl)-amino]-acetylamino}-3-(1h-imidazol-4-yl)-propionic acid methyl ester)
分子名称: Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-L-histidinate
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-02-24
公開日2013-04-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
5WOB
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BU of 5wob by Molmil
Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
分子名称: IDE-bound Fab heavy chain, IDE-bound Fab light chain, Insulin, ...
著者McCord, L.A, Liang, W.G, Farcasanu, M, Wang, A.G, Koide, S, Tang, W.J.
登録日2017-08-01
公開日2018-04-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.95 Å)
主引用文献Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7, 2018
4IFH
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Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
分子名称: Insulin-degrading enzyme, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide, ZINC ION
著者Liang, W.G, Guo, Q, Deprez, R, Deprez, B, Tang, W.
登録日2012-12-14
公開日2013-12-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.286 Å)
主引用文献Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Nat Commun, 6, 2015
4IOF
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BU of 4iof by Molmil
Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)
分子名称: Fab-bound IDE, heavy chain, light chain, ...
著者McCord, L.A, Liang, W.G, Hoey, R, Dowdell, E, Koide, A, Koide, S, Tang, W.J.
登録日2013-01-07
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.353 Å)
主引用文献Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
Proc.Natl.Acad.Sci.USA, 110, 2013
4GS8
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BU of 4gs8 by Molmil
Structure analysis of cysteine free insulin degrading enzyme (ide) with compound bdm43079 [{[(s)-2-(1h-imidazol-4-yl)-1-methylcarbamoyl-ethylcarbamoyl]-methyl}-(3-phenyl-propyl)-amino]-acetic acid
分子名称: Insulin-degrading enzyme, N-(carboxymethyl)-N-(3-phenylpropyl)glycyl-N-methyl-L-histidinamide, ZINC ION
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GSC
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BU of 4gsc by Molmil
Structure analysis of insulin degrading enzyme with compound bdm41559 ((s)-2-[2-(carboxymethyl-phenethyl-amino)-acetylamino]-3-(1h-imidazol-4-yl)-propionic acid methyl ester)
分子名称: Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(2-phenylethyl)glycyl-L-histidinate
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis.
Eur.J.Med.Chem., 79, 2014
4GSF
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BU of 4gsf by Molmil
The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester
分子名称: Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate
著者Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J.
登録日2012-08-27
公開日2013-08-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.
Eur.J.Med.Chem., 90, 2015
7K1D
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BU of 7k1d by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_77291
分子名称: (3R)-3-{4-[(3R)-4-(3,4-difluorobenzene-1-carbonyl)morpholin-3-yl]-1H-1,2,3-triazol-1-yl}-N-hydroxy-4-(naphthalen-2-yl)butanamide, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Liang, W.G, Deprez, R, Bosc, D, Tang, W.
登録日2020-09-07
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 2
To Be Published
7K1F
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BU of 7k1f by Molmil
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88558
分子名称: 1,4-DIETHYLENE DIOXIDE, 3,4-difluoro-N-({1-[(2R)-4-(hydroxyamino)-4-oxo-1-(quinolin-7-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)benzamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Liang, W.G, Deprez, R, Bosc, D, Tang, W.
登録日2020-09-07
公開日2021-09-22
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 4
To Be Published

 

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