2WK3

Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)

Summary for 2WK3

Entry DOI	10.2210/pdb2wk3/pdb
Related	1AAP 1AMB 1AMC 1AML 1BA4 1BA6 1BJB 1BJC 1BRC 1CA0 1HZ3 1IYT 1MWP 1OWT 1QCM 1QWP 1QXC 1QYT 1RW6 1TAW 1TKN 1UO7 1UO8 1UOA 1UOI 1X11 1ZE7 1ZE9 1ZJD 2BEG 2BOM 2BP4 2JBU 2JG4 2WBY 2WC0
Descriptor	INSULIN DEGRADING ENZYME, BETA-AMYLOID PROTEIN 42, ZINC ION, ... (4 entities in total)
Functional Keywords	metal-binding, metalloprotease, ide, protease, hydrolase, amyloid-beta (1-42)
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm: P14735 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	4
Total formula weight	245108.32
Authors	Guo, Q.,Tang, W.J. (deposition date: 2009-06-05, release date: 2009-11-03, Last modification date: 2011-07-13)
Primary citation	Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J. Molecular Basis for the Recognition and Cleavages of Igf-II, Tgf-Alpha, and Amylin by Human Insulin Degrading Enzyme. J.Mol.Biol., 395:430-, 2010 Cited by PubMed: 19896952 DOI: 10.1016/J.JMB.2009.10.072 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation