2WC0

crystal structure of human insulin degrading enzyme in complex with iodinated insulin

Summary for 2WC0
Related1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2H67 2HH4 2HHO 2HIU 2JBU 2JG4 2VJZ 2VK0 2WBY 3AIY 4AIY 5AIY
DescriptorINSULIN-DEGRADING ENZYME, INSULIN A CHAIN, INSULIN B CHAIN, ... (6 entities in total)
Functional Keywordshydrolase/hormone, zinc, dioxane, insulin, hormone, protease, secreted, human insulin-degrading enzyme, disulfide bond, metalloprotease, glucose metabolism, carbohydrate metabolism, hydrolase, cytoplasm, polymorphism, metal-binding, cleavage on pair of basic residues, hydrolase-hormone complex
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationCytoplasm: P14735
Secreted: P01308 P01308
Total number of polymer chains6
Total formula weight241592.12
Authors
Manolopoulou, M.,Guo, Q.,Malito, E.,Schilling, A.B.,Tang, W.J. (deposition date: 2009-03-06, release date: 2009-03-24, Last modification date: 2011-07-13)
Primary citationGuo, Q.,Malito, E.,Manolopoulou, M.,Schilling, A.B.,Tang, W.J.
Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme.
J.Biol.Chem., 284:14177-, 2009
PubMed: 19321446
DOI: 110.1074/JBC.M900068200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation
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PDB entries from 2021-06-16