1QIY

HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL

Summary for 1QIY
Related1QIZ 1QJ0
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ... (6 entities in total)
Functional Keywordshormone, glucose metabolism, diabetes, insulin mutant
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationSecreted: P01308 P01308
Total number of polymer chains12
Total formula weight35822.46
Authors
Tang, L.,Whittingham, J.L.,Verma, C.S.,Caves, L.S.D.,Dodson, G.G. (deposition date: 1999-06-18, release date: 1999-06-22, Last modification date: 2017-07-05)
Primary citationCaves, L.S.D.,Dodson, G.G.,Tang, L.,Verma, C.S.,Whittingham, J.L.
Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38:12041-, 1999
PubMed: 10508408
DOI: 110.1021/BI990700K
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-23