1QIY

HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL

Summary for 1QIY

Related1QIZ 1QJ0
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ... (6 entities in total)
Functional Keywordshormone, glucose metabolism, diabetes, insulin mutant
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01308 P01308
Total number of polymer chains12
Total molecular weight35822.46
Authors
Tang, L.,Whittingham, J.L.,Verma, C.S.,Caves, L.S.D.,Dodson, G.G. (deposition date: 1999-06-18, release date: 1999-06-22, Last modification date: 2017-07-05)
Primary citation
Tang, L.,Whittingham, J.L.,Verma, C.S.,Caves, L.S.D.,Dodson, G.G.
Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.
Biochemistry, 38:12041-, 1999
PubMed: 10508408 (PDB entries with the same primary citation)
DOI: 10.1021/BI990700K
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers61.1%13.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution