1QIY

HUMAN INSULIN HEXAMERS WITH CHAIN B HIS MUTATED TO TYR COMPLEXED WITH PHENOL

Summary for 1QIY

• Entry DOI: 10.2210/pdb1qiy/pdb
• Related: 1QIZ 1QJ0
• Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ... (6 entities in total)
• Functional Keywords: hormone, glucose metabolism, diabetes, insulin mutant
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 12
• Total formula weight: 35822.46

Authors

Tang, L.,Whittingham, J.L.,Verma, C.S.,Caves, L.S.D.,Dodson, G.G. (deposition date: 1999-06-18, release date: 1999-06-22, Last modification date: 2017-07-05)

• Primary citation: Tang, L.,Whittingham, J.L.,Verma, C.S.,Caves, L.S.D.,Dodson, G.G.; Structural Consequences of the B5 Histidine --> Tyrosine Mutation in Human Insulin Characterized by X-Ray Crystallography and Conformational Analysis.; Biochemistry, 38:12041-, 1999; PubMed: 10508408; DOI: 10.1021/BI990700K

Experimental method

X-RAY DIFFRACTION (2.3 Å)