1SF1

NMR STRUCTURE OF HUMAN INSULIN under Amyloidogenic Condition, 15 STRUCTURES

Summary for 1SF1
Related2HIU
DescriptorINSULIN A CHAIN, Insulin (2 entities in total)
Functional Keywordshormone, human insulin, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5817.65
Authors
Weiss, M.A.,Hua, Q.X. (deposition date: 2004-02-19, release date: 2004-03-30, Last modification date: 2011-07-13)
Primary citationHua, Q.X.,Weiss, M.A.
Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate
J.Biol.Chem., 279:21449-21460, 2004
PubMed: 14988398
DOI: 110.1074/jbc.M314141200
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-23