1T1P

NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES

Summary for 1T1P
Related1LNP 1T1K 1T1Q
NMR InformationBMRB: 6203
Descriptorinsulin, Insulin (2 entities in total)
Functional Keywordsthr-b12-dkp-insulin, protein unfolding, insulin receptor, receptor binding, hormone-growth factor complex, hormone/growth factor
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5796.57
Authors
Huang, K.,Xu, B.,Hu, S.Q.,Chu, Y.C.,Hua, Q.X.,Whittaker, J.,Nakagawa, S.H.,De Meyts, P.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2004-04-16, release date: 2004-08-10, Last modification date: 2011-07-13)
Primary citationChu, Y.C.,De Meyts, P.,Hu, S.Q.,Hua, Q.X.,Huang, K.,Katsoyannis, P.G.,Li, B.,Nakagawa, S.H.,Qu, Y.,Theede, A.M.,Wang, R.Y.,Wang, S.,Weiss, M.A.,Whittaker, J.,Xu, B.
How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341:529-550, 2004
PubMed: 15276842
DOI: 110.1016/j.jmb.2004.05.023
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation
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PDB entries from 2021-06-16