1T1P

NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES

Summary for 1T1P

Related1LNP 1T1K 1T1Q
Descriptorinsulin, Insulin (2 entities in total)
Functional Keywordsthr-b12-dkp-insulin, protein unfolding, insulin receptor, receptor binding, hormone-growth factor complex, hormone/growth factor
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5796.57
Authors
Huang, K.,Xu, B.,Hu, S.Q.,Chu, Y.C.,Hua, Q.X.,Whittaker, J.,Nakagawa, S.H.,De Meyts, P.,Katsoyannis, P.G.,Weiss, M.A. (deposition date: 2004-04-16, release date: 2004-08-10, Last modification date: 2011-07-13)
Primary citation
Huang, K.,Xu, B.,Hu, S.Q.,Chu, Y.C.,Hua, Q.X.,Qu, Y.,Li, B.,Wang, S.,Wang, R.Y.,Nakagawa, S.H.,Theede, A.M.,Whittaker, J.,De Meyts, P.,Katsoyannis, P.G.,Weiss, M.A.
How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341:529-550, 2004
PubMed: 15276842 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2004.05.023
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers965.6%31.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 1t1p
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Molmil generated image of 1t1p
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Molmil generated image of 1t1p
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