Solution structure of the monomeric [Thr(B27)->Pro,Pro(B28)->Thr] insulin mutant (PT insulin)

Summary for 1JCO
NMR InformationBMRB: 4997
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordshelix-turn-helix, coil-helix-coil, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5817.65
Keller, D.,Clausen, R.,Josefsen, K.,Led, J.J. (deposition date: 2001-06-11, release date: 2001-10-03, Last modification date: 2011-07-13)
Primary citationClausen, R.,Josefsen, K.,Keller, D.,Led, J.J.
Flexibility and bioactivity of insulin: an NMR investigation of the solution structure and folding of an unusually flexible human insulin mutant with increased biological activity.
Biochemistry, 40:10732-10740, 2001
PubMed: 11524020
DOI: 110.1021/bi0108150
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-16