NMR structure of human insulin mutant GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures

Summary for 2HHO
DescriptorInsulin A chain, Insulin B chain (2 entities in total)
Functional Keywordshormone, human insulin, mutant, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5824.62
Hua, Q.X.,Nakagawa, S.,Hu, S.Q.,Jia, W.,Weiss, M.A. (deposition date: 2006-06-28, release date: 2006-07-18, Last modification date: 2011-07-13)
Primary citationHu, S.Q.,Hua, Q.X.,Jia, W.,Nakagawa, S.,Wang, S.,Weiss, M.A.
Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281:24900-24909, 2006
PubMed: 16762918
DOI: 110.1074/jbc.M602691200
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-23