2JBU
Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.
Summary for 2JBU
Entry DOI | 10.2210/pdb2jbu/pdb |
Descriptor | INSULIN-DEGRADING ENZYME, CO-PURIFIED PEPTIDE, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total) |
Functional Keywords | metal-binding, metalloprotease, zinc, protease, hydrolase, enzyme assay, insulin degrading enzyme |
Biological source | Homo sapiens More |
Total number of polymer chains | 4 |
Total formula weight | 231348.39 |
Authors | Im, H.,Shen, Y.,Tang, W.J. (deposition date: 2006-12-11, release date: 2007-07-03, Last modification date: 2023-12-13) |
Primary citation | Im, H.,Manolopoulou, M.,Malito, E.,Shen, Y.,Zhao, J.,Neant-Fery, M.,Sun, C.-Y.,Meredith, S.C.,Sisodia, S.S.,Leissring, M.A.,Tang, W.J. Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282:25453-, 2007 Cited by PubMed: 17613531DOI: 10.1074/JBC.M701590200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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