2JBU

Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	INSULIN-DEGRADING ENZYME	polymer	990	114715.1	2	UniProt (Q5T5N2) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) UniProt (by SIFTS) (P14735)	Homo sapiens
2	C, D (C, D)	CO-PURIFIED PEPTIDE	polymer	12	870.9	2		Escherichia coli
3	E, F (A, B)	1,4-DIETHYLENE DIOXIDE	non-polymer		88.1	2	Chemie (DIO)
4	G, H, I (A, B, D)	water	water		18.0	80	Chemie (HOH)

Sequence modifications

A, B: 30 - 41 (PDB: 2JBU)
A, B: 42 - 1019 (UniProt: Q5T5N2)

PDB	External Database	Details
Gln 111	Glu 111	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	231172.2
Non-Polymers*	Number of molecules	2
	Total formula weight	176.2
All*	Total formula weight	231348.4

*Water molecules are not included.