2JBU

Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.

Summary for 2JBU

DescriptorINSULIN-DEGRADING ENZYME, CO-PURIFIED PEPTIDE, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
Functional Keywordsmetal-binding, metalloprotease, zinc, protease, hydrolase, enzyme assay, insulin degrading enzyme
Biological sourceHomo sapiens
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Total number of polymer chains4
Total molecular weight231348.39
Authors
Im, H.,Shen, Y.,Tang, W.J. (deposition date: 2006-12-11, release date: 2007-07-03, Last modification date: 2018-03-07)
Primary citation
Im, H.,Manolopoulou, M.,Malito, E.,Shen, Y.,Zhao, J.,Neant-Fery, M.,Sun, C.-Y.,Meredith, S.C.,Sisodia, S.S.,Leissring, M.A.,Tang, W.J.
Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282:25453-, 2007
PubMed: 17613531 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M701590200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.219221.6%6.1%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report