1TAW
BOVINE TRYPSIN COMPLEXED TO APPI
Summary for 1TAW
Entry DOI | 10.2210/pdb1taw/pdb |
Descriptor | TRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | serine protease, kunitz type inhibitor, complex, protease-substrate interactions, complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor) |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00760 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 2 |
Total formula weight | 29770.53 |
Authors | Hynes, T.R.,Kossiakoff, A.A. (deposition date: 1996-12-19, release date: 1997-06-24, Last modification date: 2023-08-09) |
Primary citation | Scheidig, A.J.,Hynes, T.R.,Pelletier, L.A.,Wells, J.A.,Kossiakoff, A.A. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6:1806-1824, 1997 Cited by PubMed: 9300481PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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