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1TAW

BOVINE TRYPSIN COMPLEXED TO APPI

Summary for 1TAW
Entry DOI10.2210/pdb1taw/pdb
DescriptorTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, CALCIUM ION, ... (4 entities in total)
Functional Keywordsserine protease, kunitz type inhibitor, complex, protease-substrate interactions, complex (serine protease-inhibitor) complex, complex (serine protease/inhibitor)
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00760
Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains2
Total formula weight29770.53
Authors
Hynes, T.R.,Kossiakoff, A.A. (deposition date: 1996-12-19, release date: 1997-06-24, Last modification date: 2023-08-09)
Primary citationScheidig, A.J.,Hynes, T.R.,Pelletier, L.A.,Wells, J.A.,Kossiakoff, A.A.
Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Protein Sci., 6:1806-1824, 1997
Cited by
PubMed: 9300481
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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