7K1E

Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646

Summary for 7K1E

• Entry DOI: 10.2210/pdb7k1e/pdb
• Descriptor: Insulin-degrading enzyme, ZINC ION, 3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}ethyl]benzamide, ... (6 entities in total)
• Functional Keywords: hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 231226.20

Authors

Liang, W.G.,Deprez, R.,Bosc, D.,Tang, W. (deposition date: 2020-09-07, release date: 2021-09-22, Last modification date: 2023-10-18)

• Primary citation: Liang, W.G.,Deprez, R.,Bosc, D.,Tang, W.; Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 3; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)