2JG4

Substrate-free IDE structure in its closed conformation

Summary for 2JG4

DescriptorINSULIN DEGRADING ENZYME, ZINC ION, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
Functional Keywordshydrolase, metal-binding, metalloprotease, protease, zinc
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P14735
Total number of polymer chains2
Total molecular weight229883.52
Authors
Malito, E.,Tang, W.J. (deposition date: 2007-02-07, release date: 2007-07-03, Last modification date: 2011-07-13)
Primary citation
Im, H.,Manolopoulou, M.,Malito, E.,Shen, Y.,Zhao, J.,Neant-Fery, M.,Sun, C.-Y.,Meredith, S.C.,Sisodia, S.S.,Leissring, M.A.,Tang, W.J.
Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide
J.Biol.Chem., 282:25453-, 2007
PubMed: 17613531 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M701590200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers70.2%7.0%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2jg4
no rotation
Molmil generated image of 2jg4
rotated about x axis by 90°
Molmil generated image of 2jg4
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2jg4
no rotation
Molmil generated image of 2jg4
rotated about x axis by 90°
Molmil generated image of 2jg4
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2jg4.pdb1.gz [165.04 KB])
Coordinate files for Biological unit (2jg4.pdb2.gz [162.11 KB])
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