2JG4

Substrate-free IDE structure in its closed conformation

Summary for 2JG4

Entry DOI	10.2210/pdb2jg4/pdb
Descriptor	INSULIN DEGRADING ENZYME, ZINC ION, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
Functional Keywords	hydrolase, metal-binding, metalloprotease, protease, zinc
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	229883.52
Authors	Malito, E.,Tang, W.J. (deposition date: 2007-02-07, release date: 2007-07-03, Last modification date: 2023-12-13)
Primary citation	Im, H.,Manolopoulou, M.,Malito, E.,Shen, Y.,Zhao, J.,Neant-Fery, M.,Sun, C.-Y.,Meredith, S.C.,Sisodia, S.S.,Leissring, M.A.,Tang, W.J. Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282:25453-, 2007 Cited by PubMed: 17613531 DOI: 10.1074/JBC.M701590200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation