2JG4

Substrate-free IDE structure in its closed conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	INSULIN DEGRADING ENZYME	polymer	990	114700.1	2	UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) In PDB	HOMO SAPIENS (HUMAN)	INSULYSIN, INSULINASE, INSULIN PROTEASE
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	1,4-DIETHYLENE DIOXIDE	non-polymer		88.1	4	Chemie (DIO)
4		water	water		18.0	427	Chemie (HOH)

Sequence modifications

A, B: 30 - 42 (PDB: 2JG4)
A, B: 43 - 1019 (UniProt: P14735)

PDB	External Database	Details
Ile 78	Met 77	conflict
Ala 555	Val 554	conflict
Phe 567	Lys 566	conflict
Phe 568	Lys 567	conflict
Leu 569	Lys 568	conflict
Phe 831	Tyr 830	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	229400.3
Non-Polymers*	Number of molecules	6
	Total formula weight	483.2
All*	Total formula weight	229883.5

*Water molecules are not included.