4LTE

Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor

Summary for 4LTE

Entry DOI	10.2210/pdb4lte/pdb
Related PRD ID	PRD_001215
Descriptor	Insulin-degrading enzyme, Macrocyclic Inhibitor, ZINC ION, ... (7 entities in total)
Functional Keywords	hydrolase, metal-binding, metalloprotease, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P14735
Total number of polymer chains	4
Total formula weight	228603.25
Authors	Foda, Z.H.,Seeliger, M.A.,Saghatelian, A.,Liu, D.R. (deposition date: 2013-07-23, release date: 2014-05-21, Last modification date: 2024-04-24)
Primary citation	Maianti, J.P.,McFedries, A.,Foda, Z.H.,Kleiner, R.E.,Du, X.Q.,Leissring, M.A.,Tang, W.J.,Charron, M.J.,Seeliger, M.A.,Saghatelian, A.,Liu, D.R. Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature, 511:94-98, 2014 Cited by PubMed: 24847884 DOI: 10.1038/nature13297 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.705 Å)

Structure validation