4DTT

Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367

Summary for 4DTT

Entry DOI	10.2210/pdb4dtt/pdb
Related	4DTV
Descriptor	Insulin-degrading enzyme, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, ... (4 entities in total)
Functional Keywords	metalloprotease, zinc binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14735
Total number of polymer chains	2
Total formula weight	230751.51
Authors	Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (deposition date: 2012-02-21, release date: 2013-02-27, Last modification date: 2023-09-13)
Primary citation	Charton, J.,Gauriot, M.,Guo, Q.,Hennuyer, N.,Marechal, X.,Dumont, J.,Hamdane, M.,Pottiez, V.,Landry, V.,Sperandio, O.,Flipo, M.,Buee, L.,Staels, B.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R. Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79:184-193, 2014 Cited by PubMed: 24735644 DOI: 10.1016/j.ejmech.2014.04.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.22 Å)

Structure validation