4M1C
Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40)
Summary for 4M1C
Entry DOI | 10.2210/pdb4m1c/pdb |
Related | 4IOF |
Descriptor | Insulin-degrading enzyme, Fab-bound IDE, heavy chain, Fab-bound IDE, light chain, ... (5 entities in total) |
Functional Keywords | hydrolase, zinc metalloprotease |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P14735 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 8 |
Total formula weight | 346291.21 |
Authors | McCord, L.M.,Liang, W.,Farcasanu, M.,Scherpelz, K.,Meredith, S.C.,Koide, S.,Tang, W.J. (deposition date: 2013-08-02, release date: 2014-08-06, Last modification date: 2023-09-20) |
Primary citation | McCord, L.A.,Liang, W.,Farcasanu, M.,Scherpelz, K.,Meredith, S.C.,Koide, S.,Tang, W.J. Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) To be Published, |
Experimental method | X-RAY DIFFRACTION (3.5007 Å) |
Structure validation
Download full validation report