4IOF

Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)

Summary for 4IOF

Entry DOI	10.2210/pdb4iof/pdb
Descriptor	Insulin-degrading enzyme, Fab-bound IDE, heavy chain, Fab-bound IDE, light chain, ... (5 entities in total)
Functional Keywords	hydrolase, zinc metalloprotease
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: P14735
Total number of polymer chains	6
Total formula weight	337556.07
Authors	McCord, L.A.,Liang, W.G.,Hoey, R.,Dowdell, E.,Koide, A.,Koide, S.,Tang, W.J. (deposition date: 2013-01-07, release date: 2013-07-24, Last modification date: 2023-09-20)
Primary citation	McCord, L.A.,Liang, W.G.,Dowdell, E.,Kalas, V.,Hoey, R.J.,Koide, A.,Koide, S.,Tang, W.J. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proc.Natl.Acad.Sci.USA, 110:13827-13832, 2013 Cited by PubMed: 23922390 DOI: 10.1073/pnas.1304575110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.353 Å)

Structure validation