4IOF
Crystal structure analysis of Fab-bound human Insulin Degrading Enzyme (IDE)
Summary for 4IOF
Entry DOI | 10.2210/pdb4iof/pdb |
Descriptor | Insulin-degrading enzyme, Fab-bound IDE, heavy chain, Fab-bound IDE, light chain, ... (5 entities in total) |
Functional Keywords | hydrolase, zinc metalloprotease |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 6 |
Total formula weight | 337556.07 |
Authors | McCord, L.A.,Liang, W.G.,Hoey, R.,Dowdell, E.,Koide, A.,Koide, S.,Tang, W.J. (deposition date: 2013-01-07, release date: 2013-07-24, Last modification date: 2023-09-20) |
Primary citation | McCord, L.A.,Liang, W.G.,Dowdell, E.,Kalas, V.,Hoey, R.J.,Koide, A.,Koide, S.,Tang, W.J. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme. Proc.Natl.Acad.Sci.USA, 110:13827-13832, 2013 Cited by PubMed: 23922390DOI: 10.1073/pnas.1304575110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.353 Å) |
Structure validation
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