3QZ2
The structure of cysteine-free human insulin degrading enzyme
Summary for 3QZ2
| Entry DOI | 10.2210/pdb3qz2/pdb |
| Descriptor | Insulin-degrading enzyme, ZINC ION (3 entities in total) |
| Functional Keywords | insulin degrading enzyme, hydrolase |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P14735 |
| Total number of polymer chains | 2 |
| Total formula weight | 229253.94 |
| Authors | Guo, Q.,Tang, W.J. (deposition date: 2011-03-04, release date: 2012-01-25, Last modification date: 2024-02-21) |
| Primary citation | Charton, J.,Gauriot, M.,Guo, Q.,Hennuyer, N.,Marechal, X.,Dumont, J.,Hamdane, M.,Pottiez, V.,Landry, V.,Sperandio, O.,Flipo, M.,Buee, L.,Staels, B.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R. Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79:184-193, 2014 Cited by PubMed: 24735644DOI: 10.1016/j.ejmech.2014.04.009 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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